Early embryology; cell migration controls (Introduction)

by David Turell , Tuesday, September 28, 2021, 18:28 (1152 days ago) @ David Turell

The first studies:

https://phys.org/news/2021-09-advanced-microscopy-reveals-molecular-tight.html

"Cell migration is fundamental for the existence of multicellular animals, including humans, as certain cells migrate throughout the embryo to form specific tissues. It is also crucial for human health throughout life—for example during acute wound healing. Its deregulation allows cancer cells to leave the primary tumor and colonize distant sites (cancer metastasis).

"Even though cell migration has been studied for a long time, how it is tightly controlled is not well understood. The polymerisation of a protein (actin) network behind the plasma membrane provides the pushing force for membrane protrusion and, consequently, cell migration.

"The research by the Krause, Stramer and Ameer-Beg Labs shows that this tight control of cell migration is mediated by the Nance-Horan Syndrome-like 1 (NHSL1) protein which inhibits the initiation of actin polymerisation at the leading edge of migrating cells. NHSL1 belongs to the poorly investigated Nance-Horan Syndrome protein family along with Nance-Horan Syndrome (NHS) and NHSL2 proteins. Mutations in the NHS gene cause Nance-Horan syndrome, which is characterized by dental abnormalities, developmental delay, and congenital cataracts.

"The scientists are now turning to NHS to study whether deregulated cell migration may play a role in the pathogenesis of Nance-Horan Syndrome. In addition, they are investigating whether the Nance-Horan Syndrome protein family act as tumor suppressors because deregulation of cell migration is a hallmark of cancer metastasis, and NHSL1 is required for tight control of cell migration."

Comment: all systems have go no-go controls or feedback loops. It is easy to predict that new research will discover them as designed. Just shows how a field of work starts.