Epigenetics: Father's stress affects offspring' brain (Introduction)

by David Turell , Saturday, February 17, 2018, 22:36 (2472 days ago) @ David Turell

The stress causes changes in sperm as described in this study in mice:

https://www.sciencedaily.com/releases/2018/02/180216110547.htm

"New research in mice has found that a father's stress affects the brain development of his offspring. This stress changes the father's sperm, which can then alter the brain development of the child. This new research provides a much better understanding of the key role that fathers play in the brain development of offspring.

"Scientists have known that a mother's environment during pregnancy, including factors such as poor diet, stress or infection, can cause damage negatively impact her offspring. This may be due in part to how this environment affects the expression of certain genes -- known as epigenetics.

***

"Previously, Bale had found that adult male mice experiencing chronic periods of mild stress have offspring with a reduced response to stress; changes in stress reactivity have been linked to some neuropsychiatric disorders, including depression and PTSD. She and her colleagues isolated the mechanism of the reduced response; they found that the father's sperm showed changes in genetic material known as microRNA. MicroRNA are important because they play a key role in which genes become functional proteins.

"Now, Bale and her colleagues have unraveled new details about these microRNA changes. In the male reproductive tract, the caput epididymis, the structure where sperm matures, releases tiny vesicles packed with microRNA that can fuse with sperm to change its cargo delivered to the egg. The caput epididymis responded to the father's stress by altering the content of these vesicles.

"This suggests that even mild environmental challenges can have a significant impact on the development and potentially the health of future offspring."

Comment: Lamarck is alive and well.