The James Shapiro approach to evolutionary change. It was never random mutation and natural selection:-http://www.huffingtonpost.com/james-a-shapiro/inconvenient-truths-why-a_b_2228277.html-Note the comments on bacterial resistance:-"He seemed to have no idea that bacterial antibiotic resistance evolves by horizontal transfer of plasmids and the accumulation of multiple resistance determinants by transposition and site-specific recombination"