Back to Shapiro: an editing bacterium (Evolution)

by David Turell , Monday, November 23, 2020, 17:28 (1242 days ago) @ David Turell

A giant bacterium alters DNA:

https://www.sciencedaily.com/releases/2020/11/201119141705.htm

The largest freshwater bacterium, Achromatium oxaliferum, is highly flexible in its requirements, as researchers have now discovered: It lives in places that differ extremely in environmental conditions such as hot springs and ice water. The adaptation is probably achieved by a process which is unique to these bacteria: only relevant genes are enriched in the genomes and transcribed, while others are archived in cell compartments.

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Achromatium is special in many respects: It is 30,000 times larger than its "normal" counterparts that live in water and owing to its calcite deposits it is visible to the naked eye. It has several hundred chromosomes, which are most likely not identical. This makes Achromatium the only known bacterium with several different genomes.

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"We suggest environmental adaptation in Achromatium occurs by increasing the copy number of relevant genes across the cell's hundreds of chromosomes. This is in stark contrast to other bacteria which eventually lose irrelevant genes. So the high number of genomes makes the versatility possible," explains Dr. Danny Ionescu, leader of the study from IGB.

Achromatium is full of calcium carbonate crystals that are located between the outer and cytoplasmic membranes. These crystals fold the cytoplasmic membrane forming pockets of cytoplasm which the researchers suggest to hold clusters of chromosomes. They hypothesize that these clusters enable Achromatium to "archive" genes of no immediate use.

"The functional versatility of Achromatium and its genomic features contradict what we know for other bacteria, for example the concept of bacterial species and the driving forces of bacterial speciation. In Achromatium, mother and daughter cells are likely not identical and each cell is unique holding a multitude of genes, some of which are not essential for life in a particular habitat. Therefore, each cell keeps the potential to rapidly adapt to changing or new environmental conditions," concludes Professor Hans-Peter Grossart, co-author of the study and head of the aquatic microbial ecology group at IGB.

Comment: This a very specialized bacterium. But it fits Shapiro to a 'T'.