Heritable epigenetics (Introduction)

by David Turell @, Monday, November 05, 2012, 15:06 (4402 days ago)

More evidence from rats and nicotine:-http://www.the-scientist.com/?articles.view/articleNo/33123/title/Dangers-of-Second-Generation-Smoke/

Heritable epigenetics

by David Turell @, Monday, December 24, 2012, 15:37 (4353 days ago) @ David Turell

Excellent article reviewing all the way epigenetic changes are inheritable:-http://www.the-scientist.com/?articles.view/articleNo/32637/title/Lamarck-and-the-Missing-Lnc/

Heritable epigenetics

by David Turell @, Tuesday, December 25, 2012, 14:39 (4352 days ago) @ David Turell

Alternative splicing of exons changes the meaning of simply expecting one gene, one protein. By splicing exons together and removing the introns taht are inbetween, the genome can make anyting, even different species. Did evolution make this mechanism as life developed or was the splicosome there from the beginning, and is the source of complexification? I have predicted we would find such a mechanism? It is an easy jump for me to say God created the genome to act this way
"After analyzing vast amounts of genetic data, the researchers found that the same genes are expressed in the same tissue types, such as liver or heart, across mammalian species. However, alternative splicing patterns—which determine the segments of those genes included or excluded—vary from species to species. "The core things that make a heart a heart are mostly determined by a heart-specific gene expression signature. But the core things that make a mouse a mouse may disproportionately derive from splicing patterns that differ from those of rats or other mammals" says Chris Burge, an MIT professor of biology and biological engineering, and senior author of a paper on the findings in the Dec. 20 online edition of Science."- Read more at: http://phys.org/news/2012-12-evolution-alternative-splicing-rna-rewires.html#jCp

Heritable epigenetics;alternative splicing

by David Turell @, Saturday, December 29, 2012, 22:00 (4348 days ago) @ David Turell
edited by unknown, Saturday, December 29, 2012, 22:05

Alternative splicing of exons changes the meaning of simply expecting one gene, one protein. By splicing exons together and removing the introns taht are inbetween, the genome can make anyting, even different species. Did evolution make this mechanism as life developed or was the splicosome there from the beginning, and is the source of complexification? I have predicted we would find such a mechanism? It is an easy jump for me to say God created the genome to act this way-Two more articles which show that our DNA may look like 98% of chimp DNA, but alternative splicing gives a whole new set of species instructions, or organ instructions:- "Blencowe's team showed that the species-specific alternative splicing changes tended to be driven by differences in the transcripts themselves, which carry a splicing code that guides the splicing machinery—rather than differences in the splicing machinery. For example, human transcripts expressed in mouse cells exhibited human, not mouse, splicing patterns, despite being spliced by mouse machinery." The bolded is a key finding.-
http://www.the-scientist.com/?articles.view/articleNo/33782/title/Evolution-by-Splicing/-Again, the observation that this mechanism was present from the beginning of life counters the theory that this degree of complexity evolved-"Scientists have wondered why vertebrate species, which look and behave very differently from one another, nevertheless share very similar repertoires of genes. For example, despite obvious physical differences, humans and chimpanzees share a nearly identical set of genes.
 
The team sequenced and compared the composition of hundreds of thousands of genetic messages in equivalent organs, such as brain, heart and liver, from 10 different vertebrate species, ranging from human to frog. They found that alternative splicing -- a process by which a single gene can give rise to multiple proteins -- has dramatically changed the structure and complexity of genetic messages during vertebrate evolution. 
The results suggest that differences in the ways genetic messages are spliced have played a major role in the evolution of fundamental characteristics of species." Again the bolded is key!-http://www.sciencedaily.com/releases/2012/12/121220144124.htm-Repeated for emphasis: Again the observation that this extremely complex mechanism was present from the beginning of life counters the theory by evolutionists that this degree of complexity in the genome evolved. It is like an airplane deciding how to build itself. No way!

Heritable epigenetics;alternative splicing

by Balance_Maintained @, U.S.A., Sunday, December 30, 2012, 02:28 (4348 days ago) @ David Turell

The number of assumptions they make is quite nauseating. The more the complexity increases the less likely it is that it could have evolved by pure random chance in the given amount of time. More importantly, they seem to forget the lower limit of evolutionary change. Any function must be survivable early in the embryonic stage in order for it to be heritable. Given that this find increases the complexity of an already overwhelmingly complex structure, shouldn't decrease the likelihood of evolution being a viable explanation by a corresponding amount?

--
What is the purpose of living? How about, 'to reduce needless suffering. It seems to me to be a worthy purpose.

Heritable epigenetics;alternative splicing

by David Turell @, Sunday, December 30, 2012, 14:34 (4347 days ago) @ Balance_Maintained

BM: Given that this find increases the complexity of an already overwhelmingly complex structure, shouldn't decrease the likelihood of evolution being a viable explanation by a corresponding amount?-Mathematically it is much worse than that. Think of the proteins, functional and necessary for life, perhaps 1,000 amino acids long. Chance combination from combinatorial space is estimated by evolutionists from 10^60's to 10^70's, way more orders of magnitude than seconds in the life of the universe, 10^18.

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