Genome complexity: looping DNA to prevent knots (Introduction)

by dhw, Thursday, April 20, 2017, 13:02 (2562 days ago) @ David Turell

QUOTE: “The models neatly explain the data flowing from high-profile projects on how different parts of the genome interact physically — which is why they've garnered so much attention.
"But these simple explanations are not without controversy. Although it has become increasingly clear that genome looping regulates gene expression, possibly contributing to cell development and diseases such as cancer, the predictions of the models go beyond what anyone has ever seen experimentally.
“For one thing, the identity of the molecular machine that forms the loops remains a mystery.” (My bold)

This article is far too specialized for me to follow in detail, but I would like to ask a straightforward question: could this unidentified “molecular machine” be the equivalent of the cell’s brain?